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Polymorphisms in the lymphotoxin alpha gene and the risk of ischemic stroke in the Japanese population. The Fukuoka Stroke Registry and the Hisayama Study.

AbstractBACKGROUND AND PURPOSE:
Lymphotoxin alpha (LTA), one of the tumor necrosis factor family proteins, is an important proinflammatory cytokine and appears to play a putative role in the inflammatory process of atherosclerosis. Recent genetic studies have suggested that variations in the gene encoding LTA, which affect its expression and biological function, may contribute to the development of vascular diseases. We conducted a case-control study to clarify the association of LTA gene polymorphisms with ischemic stroke in a large Japanese population.
METHODS:
Genotyping for LTA A252G and C804A polymorphisms was achieved by a rapid-cycle polymerase chain reaction and melting curve analysis using fluorescent probes in 1,044 incident cases of ischemic stroke recruited from the Fukuoka Stroke Registry and 1,044 age- and sex-matched control subjects recruited from the Hisayama Study.
RESULTS:
The overall distribution of allele and genotype for each polymorphism was similar between stroke patients and control subjects. The allele frequencies of 252G and 804A were slightly lower in stroke patients than in control subjects; however, conditional logistic regression analysis adjusted for potential risk factors found no association between the risk of ischemic stroke and either polymorphism. In terms of stroke subtype, we also found no association of these polymorphisms with any subtypes of ischemic stroke.
CONCLUSIONS:
Neither the A252G nor C804A polymorphism of the LTA gene was associated with stroke overall and any subtypes of ischemic stroke in the Japanese population.
AuthorsNoriko Hagiwara, Takanari Kitazono, Masahiro Kamouchi, Junya Kuroda, Tetsuro Ago, Jun Hata, Toshiharu Ninomiya, Hiroaki Ooboshi, Yasuhiro Kumai, Sohei Yoshimura, Kinya Tamaki, Kenichiro Fujii, Tetsuhiko Nagao, Yasushi Okada, Kazunori Toyoda, Hiroshi Nakane, Hiroshi Sugimori, Yoshichika Yamashita, Yoshiyuki Wakugawa, Michiaki Kubo, Yumihiro Tanizaki, Yutaka Kiyohara, Setsuro Ibayashi, Mitsuo Iida
JournalCerebrovascular diseases (Basel, Switzerland) (Cerebrovasc Dis) Vol. 25 Issue 5 Pg. 417-22 ( 2008) ISSN: 1421-9786 [Electronic] Switzerland
PMID18349535 (Publication Type: Journal Article)
Copyright(c) 2008 S. Karger AG, Basel.
Chemical References
  • Lymphotoxin-alpha
Topics
  • Aged
  • Aged, 80 and over
  • Asian People (genetics)
  • Brain Ischemia (complications, ethnology, genetics)
  • Case-Control Studies
  • Cohort Studies
  • Female
  • Gene Frequency
  • Humans
  • Japan
  • Lymphotoxin-alpha (genetics)
  • Male
  • Middle Aged
  • Polymorphism, Genetic (genetics)
  • Registries
  • Stroke (ethnology, genetics)

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