Abstract | BACKGROUND AND PURPOSE: METHODS: Genotyping for LTA A252G and C804A polymorphisms was achieved by a rapid-cycle polymerase chain reaction and melting curve analysis using fluorescent probes in 1,044 incident cases of ischemic stroke recruited from the Fukuoka Stroke Registry and 1,044 age- and sex-matched control subjects recruited from the Hisayama Study. RESULTS: The overall distribution of allele and genotype for each polymorphism was similar between stroke patients and control subjects. The allele frequencies of 252G and 804A were slightly lower in stroke patients than in control subjects; however, conditional logistic regression analysis adjusted for potential risk factors found no association between the risk of ischemic stroke and either polymorphism. In terms of stroke subtype, we also found no association of these polymorphisms with any subtypes of ischemic stroke. CONCLUSIONS: Neither the A252G nor C804A polymorphism of the LTA gene was associated with stroke overall and any subtypes of ischemic stroke in the Japanese population.
|
Authors | Noriko Hagiwara, Takanari Kitazono, Masahiro Kamouchi, Junya Kuroda, Tetsuro Ago, Jun Hata, Toshiharu Ninomiya, Hiroaki Ooboshi, Yasuhiro Kumai, Sohei Yoshimura, Kinya Tamaki, Kenichiro Fujii, Tetsuhiko Nagao, Yasushi Okada, Kazunori Toyoda, Hiroshi Nakane, Hiroshi Sugimori, Yoshichika Yamashita, Yoshiyuki Wakugawa, Michiaki Kubo, Yumihiro Tanizaki, Yutaka Kiyohara, Setsuro Ibayashi, Mitsuo Iida |
Journal | Cerebrovascular diseases (Basel, Switzerland)
(Cerebrovasc Dis)
Vol. 25
Issue 5
Pg. 417-22
( 2008)
ISSN: 1421-9786 [Electronic] Switzerland |
PMID | 18349535
(Publication Type: Journal Article)
|
Copyright | (c) 2008 S. Karger AG, Basel. |
Chemical References |
|
Topics |
- Aged
- Aged, 80 and over
- Asian People
(genetics)
- Brain Ischemia
(complications, ethnology, genetics)
- Case-Control Studies
- Cohort Studies
- Female
- Gene Frequency
- Humans
- Japan
- Lymphotoxin-alpha
(genetics)
- Male
- Middle Aged
- Polymorphism, Genetic
(genetics)
- Registries
- Stroke
(ethnology, genetics)
|