Amelioration of collagen-induced arthritis by human recombinant soluble FcgammaRIIb.

Abstract	Immune complex (IC) binding to Fc gamma receptors (FcgammaRs) is central for inflammatory reactions seen in autoimmune diseases. Consequently, a therapeutic agent with a possibility to interfere with binding of pathogenic IC to FcgammaRs would be valuable in autoimmune disorders such as rheumatoid arthritis (RA). Here we have explored the therapeutic effect of a recombinant soluble human FcgammaRIIb (sFcgammaRIIb) protein in collagen-induced arthritis (CIA). In vitro studies of the sFcgammaRIIb demonstrated binding to mouse IgG, suggesting that sFcgammaRIIb can absorb pathogenic IgG anti-collagen type II (CII) IC in vivo. Hence, administration of sFcgammaRIIb significantly reduced CIA severity compared to control treated mice. The sFcgammaRIIb treated mice had significantly less IgG anti-CII antibodies in serum and lower mRNA levels of inflammatory cytokines compared to control mice. In conclusion, sFcgammaRIIb treatment ameliorates CIA by reducing IC-stimulated inflammation and joint swelling. This suggests that recombinant sFcgammaRIIb may be useful as therapeutic agent in RA.
Authors	Sofia E Magnusson, Maria Andrén, Kajsa E Nilsson, Peter Sondermann, Uwe Jacob, Sandra Kleinau
Journal	Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 127 Issue 2 Pg. 225-33 (May 2008) ISSN: 1521-7035 [Electronic] United States
PMID	18346938 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Cytokines FCGR2B protein, human Immunoglobulin G RNA, Messenger Receptors, IgG Recombinant Proteins Ribonucleases
Topics	Animals Arthritis, Experimental (drug therapy, immunology) Arthritis, Rheumatoid (drug therapy, immunology) Cytokines (genetics, immunology) Dose-Response Relationship, Immunologic Enzyme-Linked Immunosorbent Assay Foot (pathology) Histocytochemistry Humans Immunization Immunoglobulin G (blood) Male Mice Mice, Inbred DBA RNA, Messenger (chemistry, genetics) Receptors, IgG (immunology) Recombinant Proteins (pharmacology) Ribonucleases (chemistry)

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