Abstract | PURPOSE: To investigate the kinetics and the determinants of the changes of the Clara cell 16 kDa protein (CC16) as a marker of lung injury following exposure to different toxicants. METHODS: RESULTS: Bronchiolar insult due to IPO or ANTU resulted in an initial transient increase of serum CC16, parallel to that of albumin in BALF, and a subsequent reduction in both BALF and serum. A slight reduction of CC16 in BALF was already apparent one hour following treatment with PQ. In the serum, CC16 increased to 400% of basal value. With PQ and Na(2)CrO(4), the elevation of CC16 was mainly determined by the degree of renal impairment.
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Authors | Philippe Hantson, Alfred Bernard, Cedric Hermans |
Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
Vol. 46
Issue 3
Pg. 230-8
(Mar 2008)
ISSN: 1556-3650 [Print] England |
PMID | 18344105
(Publication Type: Journal Article)
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Chemical References |
- Albumins
- Biomarkers
- Cystatins
- Scgb1a1 protein, rat
- Uteroglobin
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Topics |
- Albumins
(metabolism)
- Animals
- Biomarkers
- Bronchoalveolar Lavage Fluid
(chemistry)
- Calibration
- Cystatins
(metabolism)
- Female
- Kinetics
- Lung Diseases
(chemically induced, metabolism)
- Rats
- Rats, Sprague-Dawley
- Uteroglobin
(metabolism)
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