Abstract |
Infection with human T lymphotropic virus type I (HTLV-I) is associated with specific forms of tumours and neurological disorders, but the pathogenic activity of HTLV-II is not yet established. Moreover, due to high crossreactivity between the two viruses, differential diagnosis is not readily achieved. To discriminate between HTLV-I and HTLV-II infections, we employed synthetic peptides specific for HTLV-I and HTLV-II env regions, and the polymerase chain reaction (PCR). In a series of 962 intravenous drug addicts (IVDAs) and 50 patients with haematological malignancies, 51 and 2 samples, respectively, were reactive against HTLV-I proteins; among these, HTLV-I infection was confirmed only in 1 patient with adult T-cell lymphoma, while HTLV-II infections were identified in 6 out of 14 PCR-tested IVDAs. These findings provide evidence of HTLV-II infection among Italian IVDAs. The differentiation between HTLV-I and HTLV-II infections may contribute to a better understanding of HTLV-II pathogenicity in man.
|
Authors | A De Rossi, F Mammano, A Del Mistro, L Chieco-Bianchi |
Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 27
Issue 7
Pg. 835-8
( 1991)
ISSN: 0959-8049 [Print] England |
PMID | 1834112
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- DNA, Viral
- HTLV-I Antibodies
- HTLV-II Antibodies
|
Topics |
- AIDS Serodiagnosis
- Base Sequence
- Blotting, Western
- DNA, Viral
(analysis, genetics)
- Diagnosis, Differential
- HTLV-I Antibodies
(analysis)
- HTLV-I Infections
(diagnosis, immunology)
- HTLV-II Antibodies
(analysis)
- HTLV-II Infections
(diagnosis, genetics)
- Human T-lymphotropic virus 1
(genetics, immunology)
- Human T-lymphotropic virus 2
(genetics, immunology)
- Humans
- Polymerase Chain Reaction
- Substance-Related Disorders
(genetics, immunology)
|