HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Graves' disease with splenomegaly and pancytopenia, mimicking B-cell lymphoproliferative disease].

Abstract
A 48-year-old woman was referred to our hospital because of fever and general fatigue. Peripheral blood analysis showed a hemoglobin level of 82 g/l, a white blood cell count of 1.95 x 10(9)/l and a platelet count of 80 x 10(9)/l. There were 9% CD5-positive B-cells in peripheral blood and 35% CD10-positive B-cells in bone marrow. The patient had a high serum soluble interleukin-2 receptor (SIL-2R) level of 5,185 U/ml and splenomegaly. Lymphoproliferative disease was suspected, however monoclonal rearranged band of immunoglobulin heavy chain was not detected. She also showed hyperthyroidism, Graves' disease and then treatment with thiamazole started. However, the treatment was stopped because of agranulocytosis and she received subtotal thyroidectomy. After treatment for hyperthyroidism, serum SIL-2R level decreased to 504 U/ml and pancytopenia gradually improved. Fifteen months postoperatively, the percentage of CD5-positive B-cells in peripheral blood and CD10-positive B-cells in bone marrow decreased to 8% and 2%, respectively. This clinical course suggests that polyclonal B-cell proliferation was caused by hyperthyroidism.
AuthorsRie Ohtsuka, Yasunobu Abe, Motoaki Shiratsuchi, Youko Suehiro, Kennosuke Karube, Koichiro Muta, Junji Nishimura, Ryoichi Takayanagi
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 49 Issue 2 Pg. 104-8 (Feb 2008) ISSN: 0485-1439 [Print] Japan
PMID18341041 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biomarkers
  • CD5 Antigens
  • Receptors, Interleukin-2
  • Neprilysin
Topics
  • B-Lymphocytes (immunology)
  • Biomarkers (blood)
  • Bone Marrow Cells
  • CD5 Antigens
  • Diagnosis
  • Female
  • Graves Disease (complications)
  • Humans
  • Lymphoproliferative Disorders (diagnosis, etiology)
  • Middle Aged
  • Neprilysin
  • Pancytopenia (diagnosis, etiology)
  • Receptors, Interleukin-2 (blood)
  • Splenomegaly (etiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: