Role of adiponectin in matching of fetal and placental weight in mothers with type 1 diabetes.

Abstract

OBJECTIVE:

To assess the association of fetal hormones with placental growth and fetal weight-to-placental weight ratio index (FPI) in pregnancies complicated by maternal diabetes.

RESEARCH DESIGN AND METHODS:

We conducted a prospective study using umbilical venous blood samples taken at birth from 122 offspring of mothers with type 1 diabetes (OT1D) and 46 control subjects.

RESULTS:

Placental weight (P = 0.009) and gestation-adjusted birth weight (P < 0.001) were increased in OT1D, but FPI was unaltered (P = 0.33). Placental weight correlated with birth weight (P < 0.001) and cord leptin (P < 0.001) in control subjects and OT1D, with further relationships with cord insulin, IGF-1, IGF-binding protein-3 (IGFBP-3), and triceps and subscapular thickness in OT1D. FPI was associated with adiponectin in both groups, even after adjustment for confounders.

CONCLUSIONS:

Placental and fetal growth show a parallel increase in mothers with type 1 diabetes. The possible role of adiponectin in matching of fetal and placental growth merits further study.

• Authors: Scott M Nelson, Dilys J Freeman, Naveed Sattar, Robert S Lindsay
• Journal: Diabetes care (Diabetes Care) Vol. 31 Issue 6 Pg. 1123-5 (Jun 2008) ISSN: 1935-5548 [Electronic] United States
• PMID: 18339975 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adiponectin
• Insulin
• Leptin
• Insulin-Like Growth Factor I

Topics

• Adiponectin (blood)
• Birth Weight
• Diabetes Mellitus, Type 1 (complications, physiopathology)
• Female
• Fetal Blood (chemistry)
• Fetal Development
• Fetal Weight (physiology)
• Humans
• Infant, Newborn
• Insulin (blood)
• Insulin-Like Growth Factor I (metabolism)
• Leptin (blood)
• Organ Size
• Placenta (anatomy & histology)
• Pregnancy
• Pregnancy Complications (physiopathology)