HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Chemoprophylaxis of prosthetic joint patients during dental treatment: a decision-utility analysis.

Abstract
A decision-analytic model and a cost effectiveness analysis was performed on 1 million hypothetic prosthetic joint patients undergoing dental treatment, to determine the most cost-effective strategy to prevent late prosthetic joint infections. The cost per quality-adjusted life-year saved (QALY) was determined for three preventive strategies: no prophylaxis, oral penicillin, and oral cephalexin. The UCLA Pain-Walking-Function-Activity Scale was used to obtain quality-of-life adjustments (utility assessment) for the study population. Costs were derived from 70 patients hospitalized between July 1, 1982, and June 30, 1986, at the UCLA Center for Health Sciences. The most cost-effective preventive strategy was the no prophylaxis alternative ($196,500/QALY). However, by recommending a 1-day strategy of oral cephalexin only to those dental patients at high risk for late prosthetic joint infections rather than a 3-day regimen to all patients, the cost effectiveness improved from $1.1 million/QALY to $446,100/QALY while maintaining a low risk of death (0.38 deaths per 10(6) dental visits).
AuthorsJ J Jacobson, S O Schweitzer, C J Kowalski
JournalOral surgery, oral medicine, and oral pathology (Oral Surg Oral Med Oral Pathol) Vol. 72 Issue 2 Pg. 167-77 (Aug 1991) ISSN: 0030-4220 [Print] United States
PMID1833710 (Publication Type: Journal Article)
Chemical References
  • Penicillins
  • Cephalexin
Topics
  • Cephalexin (therapeutic use)
  • Cost-Benefit Analysis
  • Decision Trees
  • Dental Care for Disabled (economics)
  • Health Policy
  • Hip Prosthesis (economics)
  • Humans
  • Knee Prosthesis (economics)
  • Models, Statistical
  • Pain Measurement
  • Penicillins (therapeutic use)
  • Premedication
  • Prosthesis-Related Infections (economics, prevention & control)
  • Quality of Life
  • Risk Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: