Present study was designed to investigate the effect of polyherbal formulation PartySmart in experimental model of
alcoholic liver disease in male Wistar strain rats. Alcohol plus
fish oil were administered to animals for 8 weeks to induce liver injury. PartySmart was administered at doses of 250 and 500 mg/kg
body weight. After 8 weeks, parameters such as liver weight, liver function
serum markers alanine transaminase (ALT),
aspartate transaminase (AST) and
alkaline phosphatase (ALP) and lipid peroxidation were studied. Livers from all the groups were subjected for histological evaluation. Treatment with PartySmart at the dose of 500 mg/kg
body weight showed significant reduction in the levels of serum ALT, AST and ALP with a decrease in liver weight as compared to
ethanol-fed rats. A significant decrease was also observed in
malondialdehyde levels following treatment with PartySmart at 500 mg/kg
body weight. Histological profile of liver tissue in PartySmart-treated animals showed lesser vacuolar degeneration and intactness of hepatic architecture along with improved
glycogen deposition as demonstrated by PAS staining. PartySmart ameliorated alcohol-induced liver injury by preventing cell membrane disturbances, reduction of oxidative stress by
free radical scavenging and
antioxidant activity and normalization of altered intracellular redox status. Thus, PartySmart can be beneficial in the treatment of alcohol-induced liver damage.