Hypophosphatasia associated with pseudotumor cerebri and respiratory insufficiency.

Abstract

We report a 3-month-old male with infantile hypophosphatasia who later developed Pseudotumor cerebri. At the age of 3 months, he was referred to our hospital because of pneumonia and respiratory insufficiency. He had short extremities, and radiographs of the bones were consistent with lack of metaphyseal mineralization and bowed lower extremities. Vomiting and bulging fontanelle developed 3 months after admission, and CSF opening pressure was notably high at 430 mm/H2O. Hypophosphatasia is a very rare cause of pseudotumor cerebri. This report is the first case where PTC is associated with hypophosphatasia and responded well to corticosteroid therapy.

• Authors: Serap Teber, Taner Sezer, Mehpare Kafali, Tanil Kendirli, Zeynep Siklar, Merih Berberoglu, Gonul Ocal, Gulhis Deda
• Journal: Indian journal of pediatrics (Indian J Pediatr) Vol. 75 Issue 2 Pg. 186-8 (Feb 2008) ISSN: 0973-7693 [Electronic] India
• PMID: 18334804 (Publication Type: Case Reports, Journal Article)

Chemical References

• Adrenal Cortex Hormones

Topics

• Adrenal Cortex Hormones (therapeutic use)
• Humans
• Hypophosphatasia (complications, diagnosis, drug therapy)
• Infant
• Male
• Pseudotumor Cerebri (complications, diagnosis, drug therapy)
• Respiratory Insufficiency (complications, diagnosis, drug therapy)
• Treatment Outcome