Abstract | BACKGROUND: PATIENTS AND METHODS: Necrotic tissue of the pancreas and the inflammatory ascites surrounding the pancreas were derived from 15 patients (male, 10; female, 5; mean age 46 years), who underwent laparatomy due to pancreatic necrosis after treatment for 14-21 days. Tissue/fluid samples were investigated for the concentration of the antibiotic by fluoroscopic/spectroscopic methods of registration in an HPLC system. RESULTS: The mean concentration of piperacillin/tazobactam was established as 120 mg/kg (SD+/-34) in the necrotic pancreatic tissue and as 183 mg/kg (SD+/-37) in the inflammatory pancreatic ascites. CONCLUSIONS:
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Authors | W Otto, K Komorzycki, M Krawczyk |
Journal | HPB : the official journal of the International Hepato Pancreato Biliary Association
(HPB (Oxford))
Vol. 8
Issue 1
Pg. 43-8
( 2006)
ISSN: 1365-182X [Print] England |
PMID | 18333238
(Publication Type: Journal Article)
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