Risk factors associated with surgical site infection and the development of short-term complications in macaques undergoing indwelling vascular access port placement.

Abstract

BACKGROUND:

Risk factors associated with surgical site infection (SSI) and the development of short-term complications in macaques undergoing vascular access port (VAP) placement are evaluated in this study.

METHODS:

Records from 80 macaques with VAPs were retrospectively reviewed. Logistic regression was used to identify factors associated with short-term post-operative complications.

RESULTS:

The primary outcome was SSI, which occurred in 21.6% (52.6% in the first 12 months vs. 13% thereafter) of procedures. SSI was associated with major secondary complications including VAP removal (11.4%), wound dehiscence (5.7%), and mechanical catheter occlusion (5.7%). In multivariate modeling, only surgical program progress was a statistically significant predictor of SSI, while animal compliance had a slightly protective effect.

CONCLUSIONS:

Vascular access ports have a moderate risk of complications, provided the surgical program optimizes best practices. Under complex experimental conditions, VAPs represent an important refinement, both improving animals' overall well-being and environment and reducing stress.

• Authors: M L Graham, E F Rieke, M Wijkstrom, M Dunning, T C Aasheim, M J Graczyk, K J Pilon, B J Hering
• Journal: Journal of medical primatology (J Med Primatol) Vol. 37 Issue 4 Pg. 202-9 (Aug 2008) ISSN: 0047-2565 [Print] Denmark
• PMID: 18331559 (Publication Type: Journal Article)

Topics

• Animals
• Catheters, Indwelling (adverse effects, veterinary)
• Female
• Femoral Vein (surgery)
• Macaca fascicularis (surgery)
• Macaca mulatta (surgery)
• Male
• Retrospective Studies
• Risk Factors
• Surgical Wound Infection (veterinary)