Abstract | INTRODUCTION: MATERIALS AND METHODS:
Trepanation defects of 9.4 mm diameter in the intercondylar groove of sheep femora were filled with pure and augmented (200 microg BMP-2) hyaluronic acid. As controls, empty defects and defects treated with autologous bone graft harvested from the contralateral side were used. After 3 months, the defects were analysed by fluorescence microscopy after intravital fluorescence staining, contact microradiography, histology and histomorphometry. RESULTS: Treatment of the defects with loaded and unloaded hyaluronic acid resulted in a significant lack of bone formation inside the defects. Untreated defects showed an amount of 5.1% newly formed bone, and defects treated with autologous bone graft revealed a bone content of 20%. The difference between both groups was statistically significant (P < 0.05). Furthermore, there was neither a remarkable effect in the periphery of the defects nor ectopic bone formation. CONCLUSION:
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Authors | Uwe Maus, Stefan Andereya, Sascha Gravius, Christian H Siebert, Jörg A K Ohnsorge, Christopher Niedhart |
Journal | Archives of orthopaedic and trauma surgery
(Arch Orthop Trauma Surg)
Vol. 128
Issue 12
Pg. 1461-6
(Dec 2008)
ISSN: 1434-3916 [Electronic] Germany |
PMID | 18330583
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Bone Morphogenetic Protein 2
- Bone Substitutes
- Hyaluronic Acid
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Topics |
- Animals
- Bone Cysts
(therapy)
- Bone Morphogenetic Protein 2
(pharmacology)
- Bone Neoplasms
(therapy)
- Bone Regeneration
(drug effects)
- Bone Substitutes
(pharmacology)
- Bone Transplantation
(methods)
- Disease Models, Animal
- Femur
- Hyaluronic Acid
(pharmacology)
- Injections, Intralesional
- Osteogenesis
(drug effects, physiology)
- Probability
- Random Allocation
- Reference Values
- Risk Factors
- Sheep
- Transplantation, Autologous
- Treatment Failure
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