Loss of leucocyte common antigen (CD45) on atypical lymphocytes in the localized but not disseminated type of Pagetoid reticulosis.

Abstract

Atypical intraepidermal T cells in Pagetoid reticulosis did not express CD45RO, the low molecular isoform of CD45. These cells did express other CD45 isoforms in the disseminated aggressive variant (Ketron-Goodman type). The complete CD45 family was lost from the cell surface in the benign localized variant (Woringer-Kolopp type). Because the presence of CD45 is crucial for the function of the lymphocyte-specific tyrosine kinase p56lck, which is associated with lymphocyte growth and transformation, this may be the molecular basis for the non-aggressive nature of this clonal T-cell proliferation.

• Authors: W Sterry, A Hauschild
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 125 Issue 3 Pg. 238-42 (Sep 1991) ISSN: 0007-0963 [Print] England
• PMID: 1832931 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD
• Histocompatibility Antigens
• Leukocyte Common Antigens

Topics

• Adult
• Aged
• Aged, 80 and over
• Antigens, CD (analysis)
• Epidermis (immunology)
• Female
• Histocompatibility Antigens (analysis)
• Humans
• Immunoenzyme Techniques
• Leukocyte Common Antigens
• Lymphoproliferative Disorders (immunology)
• Male
• Middle Aged
• Skin (immunology)
• Skin Diseases (immunology)
• T-Lymphocytes (immunology)