Prognostic relevance of cathepsin D versus oestrogen receptors in node negative breast cancers.

Abstract

The concentration of total cathepsin D in cytosols of 199 node negative women with primary breast cancer in a 10-year retrospective cohort was assayed. Cathepsin D status alone was unable to predict disease-free or overall survival. However, those patients with receptor positive tumours who were cathepsin D positive had shorter [corrected] disease-free (P = 0.02) and overall survival (P = 0.01) than cathepsin D negative patients. Therefore, measurement of cathepsin D appears to provide additional prognostic information for the prediction of disease-free and overall survival in patients with node negative breast cancer.

• Authors: G Granata, D Coradini, V Cappelletti, G Di Fronzo
• Journal: European journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 27 Issue 8 Pg. 970-2 ( 1991) ISSN: 0959-8049 [Print] England
• PMID: 1832905 (Publication Type: Journal Article)

Chemical References

• Receptors, Estrogen
• Cathepsin D

Topics

• Breast Neoplasms (chemistry, mortality)
• Cathepsin D (analysis)
• Cohort Studies
• Female
• Humans
• Middle Aged
• Prognosis
• Receptors, Estrogen (analysis)
• Retrospective Studies
• Risk Factors