Abstract | INTRODUCTION: MATERIALS AND METHODS: Fifteen patients with radiation proctitis were enrolled. Enemas containing 150 mg rebamipide per dosing were administered after morning bowel movement, and always prior to bedtime, twice daily for 4 weeks. The efficacy of treatment was assessed from clinical symptoms (Subjective Objective Management Analysis Scale for Rectal Toxicity) and endoscopic findings. RESULTS: The mean bleeding score improved from 2.67 to 0.53 (P < 0.01). The mean symptom scores improved in those patients who had pain (0.40 to 0.13), tenesmus (0.40 to 0.20), and stool frequency (0.27 to 0.13). The mean improvement in telangiectasia scores (2.13 to 0.80, P < 0.01), bleeding point scores (1.80 to 0.27, P < 0.01), and friable mucosa scores (1.33 to 0.20, P < 0.01) were all statistically significant. No side effects were noted in any patients. CONCLUSION:
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Authors | Tae Oh Kim, Geun Am Song, Sun Mi Lee, Gwang Ha Kim, Jeong Heo, Dae Hwan Kang, Mong Cho |
Journal | International journal of colorectal disease
(Int J Colorectal Dis)
Vol. 23
Issue 6
Pg. 629-33
(Jun 2008)
ISSN: 0179-1958 [Print] Germany |
PMID | 18327596
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antioxidants
- Quinolones
- rebamipide
- Alanine
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Topics |
- Aged
- Alanine
(administration & dosage, analogs & derivatives)
- Antioxidants
(administration & dosage)
- Enema
- Female
- Genital Neoplasms, Female
(radiotherapy)
- Humans
- Middle Aged
- Proctitis
(drug therapy, pathology)
- Quinolones
(administration & dosage)
- Radiation Injuries
(drug therapy, pathology)
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