Abstract | PURPOSE: METHODS: RESULTS: Free DP and DP- micelle accumulated in the neovascularized area 1 hour to 24 hours after administration. Fluorescence of DP was weaker than that of DP- micelle. Neither DP- micelle nor DP could be detected in normal limbal vasculature. In the PDT experiments using PS, mean residual rates of corneal neovascularization were 10.1% in the mice treated with DP- micelle and 21.6% in the mice treated with free DP at 10 J/cm(2) (P < 0.01). At 50 J/cm(2), mean residual rates of corneal neovascularization were 10.6% in the mice treated with DP- micelle and 13.7% in the mice treated with free DP (P > 0.05). Although corneal neovascularization in PDT-treated mice exhibited significant regression compared with the control group, significant energy-related vessel regression with increasing laser energy could not be observed. CONCLUSIONS:
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Authors | Kenji Sugisaki, Tomohiko Usui, Nobuhiro Nishiyama, Woo-Dong Jang, Yasuo Yanagi, Satoru Yamagami, Shiro Amano, Kazunori Kataoka |
Journal | Investigative ophthalmology & visual science
(Invest Ophthalmol Vis Sci)
Vol. 49
Issue 3
Pg. 894-9
(Mar 2008)
ISSN: 0146-0404 [Print] United States |
PMID | 18326709
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- (O-methylpoly(ethylene glycol)-O'-succinyl)-N-epsilon-poly(L-lysine)
- Dendrimers
- Drug Carriers
- Metalloporphyrins
- Micelles
- Photosensitizing Agents
- zinc hematoporphyrin
- Polylysine
- Polyethylene Glycols
- Fluorescein-5-isothiocyanate
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Topics |
- Animals
- Corneal Neovascularization
(drug therapy)
- Dendrimers
- Disease Models, Animal
- Drug Carriers
- Fluorescein-5-isothiocyanate
- Male
- Metalloporphyrins
(therapeutic use)
- Mice
- Mice, Inbred C57BL
- Micelles
- Photochemotherapy
- Photosensitizing Agents
(therapeutic use)
- Polyethylene Glycols
- Polylysine
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