Case report: Congenital knee dislocation in a patient with larsen syndrome and a novel filamin B mutation.

Abstract

We treated a patient with multiple congenital joint dislocations and facial dysmorphisms consistent with Larsen syndrome. Sequencing of the FLNB gene resulted in identification of a novel, de novo 508G>C point mutation resulting in substitution of proline for a highly conserved alanine (A170P). This mutation has not been described previously but is likely causative because this alanine is highly conserved and is located in the calponin homology domain where other mutations have been described. We also report the successful use of a minimally invasive technique in achieving initial correction of bilateral congenital knee dislocations in this patient. The technique consists of serial manipulations and castings followed by an open quadriceps tenotomy. Longer followup is needed to ensure maintenance of correction and to avoid the need for more extensive surgery, which has been the traditional treatment for congenital knee dislocation associated with Larsen syndrome.

• Authors: Matthew B Dobbs, Stephanie Boehm, Dorothy K Grange, Christina A Gurnett
• Journal: Clinical orthopaedics and related research (Clin Orthop Relat Res) Vol. 466 Issue 6 Pg. 1503-9 (Jun 2008) ISSN: 1528-1132 [Electronic] United States
• PMID: 18322662 (Publication Type: Case Reports, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)

Chemical References

• Contractile Proteins
• FLNB protein, human
• Filamins
• Microfilament Proteins

Topics

• Abnormalities, Multiple (genetics)
• Contractile Proteins (genetics)
• Filamins
• Humans
• Infant
• Knee Dislocation (congenital, genetics, surgery)
• Male
• Microfilament Proteins (genetics)
• Musculoskeletal Abnormalities (genetics)
• Mutation (genetics)
• Syndrome