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Novel treatment of atrophic rhinitis: early results.

Abstract
The aim of this randomized control trial, performed at a tertiary referral hospital, was to compare the therapeutic effectiveness of two novel treatment modalities, oral rifampicin and submucosal placentrex injection, in randomly selected patients of primary atrophic rhinitis regarding objective, subjective and histopathological improvement. Patients treated with oral rifampicin showed most promising results regarding objective, subjective and histopathological improvement with maximum disease-free interval on regular follow-up as compared to submucosal placentrex injections.
AuthorsAbhishek Jaswal, Avik Kumar Jana, Biswajit Sikder, Tapan K Nandi, Sanjoy Kumar Sadhukhan, Anjan Das
JournalEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (Eur Arch Otorhinolaryngol) Vol. 265 Issue 10 Pg. 1211-7 (Oct 2008) ISSN: 0937-4477 [Print] Germany
PMID18317788 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Nucleic Acid Synthesis Inhibitors
  • Placental Extracts
  • Rifampin
Topics
  • Administration, Oral
  • Adolescent
  • Adult
  • Biopsy
  • Endoscopy
  • Female
  • Follow-Up Studies
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Nasal Mucosa
  • Nucleic Acid Synthesis Inhibitors (administration & dosage)
  • Placental Extracts (administration & dosage)
  • Rhinitis, Atrophic (drug therapy, pathology)
  • Rifampin (administration & dosage)
  • Time Factors
  • Treatment Outcome
  • Young Adult

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