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Severe hemolytic disease of the newborn from anti-e.

Abstract
Maternal antibody-mediated fetal red blood cell destruction secondary to non-D Rhesus (Rh) antibodies is a significant cause of hemolytic disease of the newborn (HDN). Here, we report a rare case of severe HDN associated with maternal antibody to Rh e. In addition to severe anemia, the infant developed thrombocytopenia, conjugated hyperbilirubinemia and cholelithiasis. Resolution of the infant's cholelithiasis occurred following treatment with ursodeoxycholic acid.
AuthorsR M McAdams, S A Dotzler, L W Winter, J D Kerecman
JournalJournal of perinatology : official journal of the California Perinatal Association (J Perinatol) Vol. 28 Issue 3 Pg. 230-2 (Mar 2008) ISSN: 0743-8346 [Print] United States
PMID18309317 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Cholagogues and Choleretics
  • Rh-Hr Blood-Group System
  • Ursodeoxycholic Acid
Topics
  • Cholagogues and Choleretics (therapeutic use)
  • Cholelithiasis (etiology)
  • Coombs Test
  • Erythroblastosis, Fetal (drug therapy, immunology, physiopathology)
  • Erythrocyte Transfusion
  • Female
  • Humans
  • Hyperbilirubinemia, Neonatal
  • Infant, Newborn
  • Phototherapy
  • Rh Isoimmunization (immunology, physiopathology)
  • Rh-Hr Blood-Group System (immunology)
  • Thrombocytopenia (etiology)
  • Ursodeoxycholic Acid (therapeutic use)

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