HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Cardiac resynchronization therapy. Midterm follow-up of 128 patients.

AbstractOBJECTIVE:
Cardiac resynchronization therapy has been used in the treatment of advanced heart failure with inter- and intraventricular dyssynchrony for more than ten years.
AIM OF THE STUDY:
A retrospective study was conducted to assess midterm results of biventricular (BiV) pacing in cardiac resynchronization therapy.
METHODS:
128 consecutive patients (age 61.0+/-9.6, 98 males), with heart failure NYHA class 2.9+/-0.4 (2.5-3.5), with LBBB, QRS> or =130 ms, with dilated cardiomyopathy--DCM (86), with coronary artery disease--CAD (36), with both these etiologies (4) and with valvular disease (2) had a BiV PM (82) or BiV ICD (46) implanted in 2000-2007. AV delay was optimized individually, using echocardiography. Before and 3 months after implantation, the following was established: NYHA class, LVEF (echocardiographically), maximum oxygen uptake (spiroergometrically), left ventricle diastolic diameter and mitral regurgitation. The average follow-up time was 25.8+/-20.8 months. Complications and 2-year survival (n=68) were also assessed.
RESULTS:
1) After 3 months of BiV pacing, NYHA class improved from 2.9+/-0.4 to 2.4+/-0.6 (n=99, p<0.001), LVEF increased from 20.2+/-4.9 to 23.9+/-6.6 % (n=92, p<0.001). Left ventricle diastolic diameter decreased from 69.8+/-8 to 67.5+/-10.0 mm (n=88, p=0.001) and mitral regurgitation was reduced from 2.2+/-0.9 to 1.9+/-0.9 (n=87, p=0.001) and maximum oxygen uptake during spiroergometry increased from 14.5+/-2.7 to 15.5+/-2.6 ml/min/kg (n=52, p=0.005). 2) Coronary sinus lead reposition was done in 2.3 %, epicardial lead implantation in 4.7 %, atrial lead reposition in 2.3 %, and right ventricular lead reposition in 2.3 % of patients. Contralateral reimplantation due to inflammatory complications in 1.6 % of patients. 3) Heart transplantation was performed on 9 patients. 4) Two-year survival was recorded in 77.9 % of 68 followed patients (72.2 % in CAD, 79.6 % in DCM).
CONCLUSION:
In the retrospective study of patients with BiV pacing a decline in heart failure, an increase in cardiac pump efficiency, reverse remodelling of left ventricle and acceptable occurrence of complications were confirmed (Tab. 4, Fig. 7, Ref. 18). Full Text (Free, PDF) www.bmj.sk
AuthorsM Novak, J Lipoldova, P Kamaryt, J Dvorak Jr, E Ozabalova, P Vank, P Hude, J Krejci
JournalBratislavske lekarske listy (Bratisl Lek Listy) Vol. 108 Issue 10-11 Pg. 445-52 ( 2007) ISSN: 0006-9248 [Print] Slovakia
PMID18306724 (Publication Type: Journal Article)
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiac Pacing, Artificial
  • Female
  • Heart Failure (physiopathology, therapy)
  • Humans
  • Male
  • Middle Aged
  • Pacemaker, Artificial

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: