Abstract | BACKGROUND & AIMS: METHODS: RESULTS: The sensitivity, specificity, and accuracy of deamidated gliadin- IgA (74%, 95%, and 86%), deamidated gliadin- IgG (65%, 98%, and 84%), and deamidated gliadin-IgA+G (75%, 94%, and 86%) were superior to gliadin- IgA (63%, 90%, and 79%) (P < .05) and gliadin- IgG (42%, 90%, and 69%) (P < .01), and were similar to tissue-transglutaminase- IgA (78%, 98%, and 90%) before treatment. The sensitivity of IgA isotype for all tests was significantly greater in celiac patients with total villous atrophy compared with those with partial villous atrophy (P < .05). The proportion of positive test results for all tests decreased significantly after treatment (P < .0001). CONCLUSIONS: Deamidated gliadin antibody is a better diagnostic test for celiac disease than the conventional gliadin antibody testing; although histopathology remains the gold standard test for diagnosis of celiac patients.
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Authors | Shadi Rashtak, Michael W Ettore, Henry A Homburger, Joseph A Murray |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 6
Issue 4
Pg. 426-32; quiz 370
(Apr 2008)
ISSN: 1542-7714 [Electronic] United States |
PMID | 18304884
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies
- Immunoglobulin A
- Immunoglobulin G
- Gliadin
- Transglutaminases
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Topics |
- Adult
- Antibodies
(blood)
- Atrophy
- Case-Control Studies
- Celiac Disease
(diagnosis, immunology)
- Child
- Enzyme-Linked Immunosorbent Assay
- Female
- Gliadin
(immunology)
- Humans
- Immunoglobulin A
(immunology)
- Immunoglobulin G
(immunology)
- Intestinal Mucosa
(pathology)
- Male
- Middle Aged
- Sensitivity and Specificity
- Severity of Illness Index
- Transglutaminases
(immunology)
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