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Antioxidant protection against acoustic trauma by coadministration of idebenone and vitamin E.

Abstract
Idebenone, a synthetic analogue of coenzyme Q, attenuates noise-induced hearing loss by virtue of its antioxidant properties. This study involves a guinea pig model of acoustic trauma where the effectiveness of idebenone is analyzed in comparison with Vitamin E (alpha-tocopherol) that exhibits a potent antioxidant activity in the inner ear. Idebenone and vitamin E were injected intraperitoneally 1 h before noise exposure and once daily for three days; functional and morphological studies were then carried out, respectively, by auditory brainstem responses evaluation, scanning electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labelling assay identification of missing and apoptotic cells was also performed. The results showed that the protective effects of idebenone and vitamin E were not additive implying that the two antioxidants may share competitive mechanisms.
AuthorsAnna R Fetoni, Aldo Ferraresi, Carmelo La Greca, Davide Rizzo, Bruno Sergi, Giuseppe Tringali, Roberto Piacentini, Diana Troiani
JournalNeuroreport (Neuroreport) Vol. 19 Issue 3 Pg. 277-81 (Feb 12 2008) ISSN: 0959-4965 [Print] England
PMID18303566 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Benzoquinones
  • Ubiquinone
  • Vitamin E
  • idebenone
Topics
  • Animals
  • Antioxidants (therapeutic use)
  • Benzoquinones (therapeutic use)
  • Drug Synergism
  • Electrophysiology
  • Guinea Pigs
  • Hearing (physiology)
  • Hearing Loss, Noise-Induced (prevention & control)
  • In Situ Nick-End Labeling
  • Microscopy, Electron, Scanning
  • Noise (adverse effects)
  • Organ of Corti (drug effects)
  • Ubiquinone (analogs & derivatives)
  • Vitamin E (therapeutic use)

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