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Dendritic cell based genetic immunization stimulates potent tumor protection dependent on CD8 CTL cells in the absence of autoimmunity.

Abstract
Although antibodies (Abs) produced by B cells can treat cancer in certain models, T cells have been accountable for the major effector to control cancer. Immune recognition toward tyrosinase-related protein-1 (TRP-1), a melanoma associated antigen up-regulated on the surface of B16F10 melanomas, generally leads to tumor protection mediated by Abs. In this study, immunization with dendritic cells ex vivo transduced with adenovirus encoding TRP-1 stimulates immune activation and potent tumor protection mediated by CD8 T cells in the absence of autoimmune consequence. Transfer of CD8 T cells from immunized mice also leads to tumor protection. The immune activation and CD8 T cell mediated tumor protection rely on the CD4 T cell help. Thus DC based genetic immunization targeting TRP-1, an antigen usually causes Ab predominant immune recognition, is capable of stimulating potent tumor protection dependent on CD8 T cells in the absence of autoimmunity.
AuthorsSheng Zhang, Weiyi Huang
JournalJournal of cancer research and clinical oncology (J Cancer Res Clin Oncol) Vol. 134 Issue 9 Pg. 987-94 (Sep 2008) ISSN: 0171-5216 [Print] Germany
PMID18299892 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cancer Vaccines
  • Oxidoreductases
  • tyrosinase-related protein-1
Topics
  • Animals
  • Autoimmunity (genetics)
  • CD4-Positive T-Lymphocytes (immunology)
  • Cancer Vaccines (genetics, immunology)
  • Dendritic Cells (immunology, transplantation)
  • Mice
  • Mice, Inbred C57BL
  • Models, Animal
  • Neoplasms, Experimental (immunology, prevention & control)
  • Oxidoreductases (genetics, immunology)
  • T-Lymphocytes, Cytotoxic (immunology)

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