Abstract |
Although antibodies (Abs) produced by B cells can treat cancer in certain models, T cells have been accountable for the major effector to control cancer. Immune recognition toward tyrosinase-related protein-1 (TRP-1), a melanoma associated antigen up-regulated on the surface of B16F10 melanomas, generally leads to tumor protection mediated by Abs. In this study, immunization with dendritic cells ex vivo transduced with adenovirus encoding TRP-1 stimulates immune activation and potent tumor protection mediated by CD8 T cells in the absence of autoimmune consequence. Transfer of CD8 T cells from immunized mice also leads to tumor protection. The immune activation and CD8 T cell mediated tumor protection rely on the CD4 T cell help. Thus DC based genetic immunization targeting TRP-1, an antigen usually causes Ab predominant immune recognition, is capable of stimulating potent tumor protection dependent on CD8 T cells in the absence of autoimmunity.
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Authors | Sheng Zhang, Weiyi Huang |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 134
Issue 9
Pg. 987-94
(Sep 2008)
ISSN: 0171-5216 [Print] Germany |
PMID | 18299892
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cancer Vaccines
- Oxidoreductases
- tyrosinase-related protein-1
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Topics |
- Animals
- Autoimmunity
(genetics)
- CD4-Positive T-Lymphocytes
(immunology)
- Cancer Vaccines
(genetics, immunology)
- Dendritic Cells
(immunology, transplantation)
- Mice
- Mice, Inbred C57BL
- Models, Animal
- Neoplasms, Experimental
(immunology, prevention & control)
- Oxidoreductases
(genetics, immunology)
- T-Lymphocytes, Cytotoxic
(immunology)
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