Long-term control of cystoid macular oedema in noninfectious uveitis with Mycophenolate Mofetil.

To evaluate the long-term safety and efficacy of Mycophenolate Mofetil (MMF) for the control of cystoid macular oedema (CMO) secondary to noninfectious uveitis (NU).
The medical records of 19 consecutive patients with inflammatory CMO treated with MMF were retrospectively reviewed. Patient demographics, best corrected visual acuity (BCVA), fluorescein angiography (FA), and optical coherence tomography (OCT) findings were evaluated.
There were eight females and 11 males with a mean age of 32.9 +/- 8.9 years. After a 1-year follow-up, 18/19 patients (31 eyes, 96.9%, P < 0.05) no longer had signs of CMO, as per their FA and OCT findings; the mean central foveal thickness (CFT) was 167.2 +/- 12.8 microm. At the last follow-up, only 3/19 patients, all affected by Behçet panuveitis, had recurrences of CMO. Mean BCVA improved from 0.34 +/- 0.14 SD at baseline to 0.65 +/- 0.2 SD at last follow-up.
MMF was safe and effective in controlling CMO and in reducing the uveitis relapse rate in patients not responding to traditional immunosuppressants. Further case-controlled studies are mandatory to validate those preliminary results.
AuthorsPiergiorgio Neri, Cesare Mariotti, Luca Cimino, Lucia Mercanti, Alfonso Giovannini
JournalInternational ophthalmology (Int Ophthalmol) Vol. 29 Issue 3 Pg. 127-33 (Jun 2009) ISSN: 1573-2630 [Electronic] Netherlands
PMID18297240 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Immunosuppressive Agents
  • mycophenolate mofetil
  • Mycophenolic Acid
  • Prednisone
  • Methylprednisolone
  • Adult
  • Anti-Inflammatory Agents (administration & dosage)
  • Disease Progression
  • Drug Therapy, Combination
  • Female
  • Humans
  • Immunosuppressive Agents (administration & dosage)
  • Macular Edema (drug therapy, etiology)
  • Male
  • Methylprednisolone (administration & dosage)
  • Mycophenolic Acid (administration & dosage, analogs & derivatives)
  • Prednisone (administration & dosage)
  • Time
  • Treatment Outcome
  • Uveitis (complications, drug therapy)

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