Long-term control of cystoid macular oedema in noninfectious uveitis with Mycophenolate Mofetil.

Abstract

PURPOSE:

To evaluate the long-term safety and efficacy of Mycophenolate Mofetil (MMF) for the control of cystoid macular oedema (CMO) secondary to noninfectious uveitis (NU).

METHODS:

The medical records of 19 consecutive patients with inflammatory CMO treated with MMF were retrospectively reviewed. Patient demographics, best corrected visual acuity (BCVA), fluorescein angiography (FA), and optical coherence tomography (OCT) findings were evaluated.

RESULTS:

There were eight females and 11 males with a mean age of 32.9 +/- 8.9 years. After a 1-year follow-up, 18/19 patients (31 eyes, 96.9%, P < 0.05) no longer had signs of CMO, as per their FA and OCT findings; the mean central foveal thickness (CFT) was 167.2 +/- 12.8 microm. At the last follow-up, only 3/19 patients, all affected by Behçet panuveitis, had recurrences of CMO. Mean BCVA improved from 0.34 +/- 0.14 SD at baseline to 0.65 +/- 0.2 SD at last follow-up.

CONCLUSIONS:

MMF was safe and effective in controlling CMO and in reducing the uveitis relapse rate in patients not responding to traditional immunosuppressants. Further case-controlled studies are mandatory to validate those preliminary results.

• Authors: Piergiorgio Neri, Cesare Mariotti, Luca Cimino, Lucia Mercanti, Alfonso Giovannini
• Journal: International ophthalmology (Int Ophthalmol) Vol. 29 Issue 3 Pg. 127-33 (Jun 2009) ISSN: 1573-2630 [Electronic] Netherlands
• PMID: 18297240 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Immunosuppressive Agents
• Mycophenolic Acid
• Prednisone
• Methylprednisolone

Topics

• Adult
• Anti-Inflammatory Agents (administration & dosage)
• Disease Progression
• Drug Therapy, Combination
• Female
• Humans
• Immunosuppressive Agents (administration & dosage)
• Macular Edema (drug therapy, etiology)
• Male
• Methylprednisolone (administration & dosage)
• Mycophenolic Acid (administration & dosage, analogs & derivatives)
• Prednisone (administration & dosage)
• Time
• Treatment Outcome
• Uveitis (complications, drug therapy)