The Ser9Gly polymorphism of the dopamine D3 receptor gene and risk of schizophrenia: an association study and a large meta-analysis.

Abstract

Dopamine D3 receptor (DRD3) binds antipsychotic drugs and is abundant in the limbic system of the brain. It has been shown to play important roles in schizophrenia. A number of studies investigated the Ser9Gly polymorphism of the DRD3 gene to test its possible association with schizophrenia; however, the results were inconsistent. Our study aims to further evaluate the possible association between the Ser9Gly polymorphism and schizophrenia using a case-control association study within the Han Chinese population as well as a meta-analysis covering all previous studies. Our study, based on 329 schizophrenic patients and 288 controls, found no significant difference in the genotype or allele distributions of Ser9Gly polymorphism, the meta-analysis showed that the Ser9Gly polymorphism was not associated with Schizophrenia. Our study does not support the contention that the Ser9Gly polymorphism of the DRD3 gene plays a major role in schizophrenia in the Chinese population.

• Authors: Gang Ma, ZangDong He, WenLi Fang, Wei Tang, Ke Huang, ZhiQiang Li, Guang He, Yifeng Xu, GuoYin Feng, Tao Zheng, Jian Zhou, Lin He, YongYong Shi
• Journal: Schizophrenia research (Schizophr Res) Vol. 101 Issue 1-3 Pg. 26-35 (Apr 2008) ISSN: 0920-9964 [Print] Netherlands
• PMID: 18295456 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptors, Dopamine D3
• Serine
• Glycine

Topics

• Adult
• Alleles
• Case-Control Studies
• China
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Glycine (genetics)
• Humans
• Male
• Meta-Analysis as Topic
• Middle Aged
• Polymorphism, Genetic
• Receptors, Dopamine D3 (genetics)
• Risk
• Schizophrenia (genetics)
• Serine (genetics)