Abstract | BACKGROUND: METHODS: In eight anesthetized and mechanically ventilated children (median age: 3.5 years; range: 2.3-6.5), we measured static respiratory system elastance (E(st)), flow resistance (R(int)), and elastance and resistance components resulting from tissue viscoelasticity (deltaE and deltaR, respectively) using the constant inflow, end-inspiratory occlusion method preceded by TLC maneuvers, both with zero PEEP (ZEEP) and PEEP (5 cm H2O) for comparison. RESULTS: With constant inspiratory flow V(I) and ZEEP, increases in end-inspiratory lung volume above relaxation volume (tidal volume, V(T)) from 8 to 20 mL x kg(-1) resulted in decreases in E(st) from 1.06 to 0.82 cm H2O x mL(-1) x kg, deltaE from 0.16 to 0.09, and R(int) from 0.13 to 0.11 cm H2O x mL(-1) x s x kg, whereas deltaR increased from 0.08 to 0.12 (P < 0.05). Similar relationships were found with PEEP. Increases in V(I) (8 to 26 mL x s(-1) x kg) with constant V(T) and ZEEP resulted in decreases in E(st) from 1.09 to 0.9 and deltaR from 0.17 to 0.06 (P < 0.01), whereas deltaE and R(int) did not change. There was a similar flow and volume dependence of elastance and resistance with PEEP. CONCLUSIONS: The observed steady decreases in E(st) with increasing V(T) (up to 16 mL/kg with PEEP) indicate marked reductions in end-expiratory relaxation volume (functional residual capacity) even with PEEP. Similarity in results with ZEEP and PEEP suggests that TLC-maneuvers and O2-N2 ventilation prevented airway closure throughout the study.
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Authors | Athanasios G Kaditis, Etsuro K Motoyama, Walter Zin, Nobuhiro Maekawa, Isuta Nishio, Taiyo Imai, Joseph Milic-Emili |
Journal | Anesthesia and analgesia
(Anesth Analg)
Vol. 106
Issue 3
Pg. 775-85, table of contents
(Mar 2008)
ISSN: 1526-7598 [Electronic] United States |
PMID | 18292419
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Airway Resistance
- Anesthesia, General
(adverse effects)
- Child
- Child, Preschool
- Elasticity
- Female
- Humans
- Lung
(physiopathology)
- Lung Compliance
- Male
- Models, Biological
- Positive-Pressure Respiration
- Pulmonary Atelectasis
(etiology, physiopathology, prevention & control)
- Respiratory Function Tests
- Respiratory Mechanics
- Total Lung Capacity
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