Beyond gastric emptying: a "toxic" lesson about gastroparesis.

Abstract

The first published controlled trial of intrapyloric botulinum toxin for gastroparesis failed to demonstrate a significant effect of treatment on symptoms, despite an improvement in gastric emptying. In this editorial, I discuss the limitations and implications of this study, with particular emphasis on what the use of botulinum toxin can teach us about the pathophysiology of gastroparesis and other gastrointestinal smooth muscle disorders.

• Authors: Pankaj J Pasricha
• Journal: The American journal of gastroenterology (Am J Gastroenterol) Vol. 103 Issue 2 Pg. 424-6 (Feb 2008) ISSN: 0002-9270 [Print] United States
• PMID: 18289204 (Publication Type: Comment, Editorial)

Chemical References

• Neuromuscular Agents
• Botulinum Toxins, Type A

Topics

• Botulinum Toxins, Type A (pharmacology, therapeutic use)
• Gastric Emptying (drug effects)
• Gastroparesis (drug therapy)
• Humans
• Neuromuscular Agents (pharmacology, therapeutic use)