Successful treatment of primary progressive follicular mucinosis with interferons.

Abstract

Follicular mucinosis is a primary idiopathic disease or a secondary, lymphoma-associated dermatosis. An effective standard therapy for the benign group is unknown. We describe a patient with primary benign disseminated progressive follicular mucinosis who was successfully treated with recombinant interferon alfa-2b and interferon-gamma. Interferons might act by down-regulation of activated inflammatory cells and/or by induction of enhanced elimination of extracellular mucin via increasing phagocytosis by macrophages.

• Authors: K Meissner, U Weyer, L Kowalzick, J Altenhoff
• Journal: Journal of the American Academy of Dermatology (J Am Acad Dermatol) Vol. 24 Issue 5 Pt 2 Pg. 848-50 (May 1991) ISSN: 0190-9622 [Print] United States
• PMID: 1828814 (Publication Type: Case Reports, Journal Article)

Chemical References

• Interferon Type I
• Interferon alpha-2
• Interferon-alpha
• Recombinant Proteins
• Interferon-gamma

Topics

• Adult
• Facial Dermatoses (therapy)
• Humans
• Injections, Intralesional
• Injections, Subcutaneous
• Interferon Type I (administration & dosage, therapeutic use)
• Interferon alpha-2
• Interferon-alpha (administration & dosage, therapeutic use)
• Interferon-gamma (administration & dosage, therapeutic use)
• Male
• Mucinosis, Follicular (therapy)
• Recombinant Proteins