The
D-dimer levels are considered to be useful for the diagnosis of
thrombosis, and they can be clinically used as a negative predictive value (NPV). However, evidence for the efficacy of diagnosing
thrombosis based on the
D-dimer levels is still not well established. The present study was designed to evaluate the cut-off values of
D-dimer levels as a negative predictor for
thrombosis. The plasma concentrations of
D-dimer were measured in inpatients suspected of having
thrombosis, and then the findings were evaluated to assess the correlation with the diagnosis of
thrombosis. In healthy volunteers, the median value of VIDAS-
D-dimer was 0.12 microg/ml, and the 95% confidence interval was from 0.05 to 0.38 microg/ml. However, the plasma
D-dimer levels were significantly higher in patients with
thrombosis than in those without
thrombosis; there was no significant difference in
D-dimer levels among various
thromboses such as
pulmonary embolism (PE),
deep vein thrombosis (DVT), and
disseminated intravascular coagulation (
DIC). The NPV for
venous thromboembolism was 100% in patients with 0.5 microg/ml VIDAS-
D-dimer and 1.2 microg/ml LPIA-
D-dimer levels. Elevated
D-dimer levels might indicate a high risk of
thrombosis, especially DVT/PE, and they are thus considered to be useful as a negative predictor for
thrombosis.