Abstract |
Osteosarcoma is the most common form of primary malignant bone tumor. The use of chemotherapy drugs with many side effects, including high-dose methotrexate, doxorubicin, cisplatin and ifosfamide, has greatly improved osteosarcoma survival compared with surgery alone. However, for 20 years, overall survival remained at a plateau of 60-70% in nonmetastatic disease and 20-30% in metastatic osteosarcoma owing to lung metastases. Liposomal muramyl tripeptide phosphatidyl ethanolamine (L-MTP-PE) is a new agent that improves overall osteosarcoma survival ( chemotherapy without L-MTP-PE 70% versus with L-MTP-PE 78%; p = 0.03). L-MTP-PE offers additional benefit for osteosarcoma treatment in combination with chemotherapy, particularly ifosfamide-containing regimens. Clinical experience indicates that side effects such as fever are temporary and controlled or prevented with ibuprofen and/or acetoaminophen premedication; severe side effects are rare. Although surgery will remain the main approach for osteosarcoma treatment of lung metastases, L-MTP-PE combined with other modalities, including chemotherapy, appears to be of benefit in these patients as well.
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Authors | Kanji Mori, Kosei Ando, Dominique Heymann |
Journal | Expert review of anticancer therapy
(Expert Rev Anticancer Ther)
Vol. 8
Issue 2
Pg. 151-9
(Feb 2008)
ISSN: 1744-8328 [Electronic] England |
PMID | 18279055
(Publication Type: Journal Article, Review)
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Chemical References |
- Liposomes
- Phosphatidylethanolamines
- mifamurtide
- Acetylmuramyl-Alanyl-Isoglutamine
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Topics |
- Acetylmuramyl-Alanyl-Isoglutamine
(administration & dosage, analogs & derivatives)
- Animals
- Bone Neoplasms
(mortality, pathology, therapy)
- Clinical Trials, Phase I as Topic
- Disease Models, Animal
- Disease-Free Survival
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Humans
- Liposomes
- Lung Neoplasms
(drug therapy, mortality, secondary)
- Male
- Osteosarcoma
(pathology, secondary, therapy)
- Phosphatidylethanolamines
(administration & dosage)
- Prognosis
- Survival Analysis
- Treatment Outcome
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