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[Expression of HOX C13 in odontogenic tumors].

AbstractPURPOSE:
To study the expression of HOXC13 mRNA in odontogenic tumors.
METHODS:
HOXC13 mRNA was detected in 47 cases of ameloblastoma (AB), 3 cases of calcifying cystic odontogenic tumor (CCOT), 3 cases of ameloblastic fibroma (AF), 10 cases of keratocystic odontogenic tumor (KCOT) and 2 cases of calcifying epithelial odontogenic tumor (CEOT) by in situ hybridization, and 7 cases of normal oral mucosa were selected as control. SPSS10.0 software package was used for chi(2) test.
RESULTS:
HOXC13 mRNA was positively expressed in all odontogenic epithelium except AF. The positive ratios were 97.9% in AB, 100% in CCOT, 100% in CEOT, 70.0% in KCOT epithelium and 42.9% in the normal oral mucosa. There was significant difference among AB, KCOT and normal mucosa (chi(2)=21.665, P<0.001).
CONCLUSIONS:
The genesis and development of odontogenic tumors are related to the high expression of HOXC13. The expression of HOXC13 mRNA in the odontogenic lesions has heterogeneity.
AuthorsYan-song Hong, Jie Wang, Jie Liu, Bo Zhang, Lin Hou, Ming Zhong
JournalShanghai kou qiang yi xue = Shanghai journal of stomatology (Shanghai Kou Qiang Yi Xue) Vol. 16 Issue 6 Pg. 587-91 (Dec 2007) ISSN: 1006-7248 [Print] China
PMID18278407 (Publication Type: Journal Article)
Chemical References
  • Homeodomain Proteins
  • RNA, Messenger
Topics
  • Ameloblastoma
  • Homeodomain Proteins (biosynthesis)
  • Humans
  • Mouth Mucosa
  • Odontogenic Cyst, Calcifying (metabolism)
  • Odontogenic Tumors (metabolism)
  • RNA, Messenger
  • Skin Neoplasms (metabolism)

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