Abstract | AIM: METHODS: Both common carotid and common femoral bifurcations have been scanned with high-resolution ultrasound in 767 volunteers over the age of 40. The latter consisted of 95% of the population of two randomly selected areas. IMTcc, IMTmax (including plaques), total plaque thickness ( TPT) (the sum of the thickest plaques present at each bifurcation in cm) and black plaque burden (BPB) ( TPT means plaque type) using the Widder classification with type 1 being the most hyperechoic and calcified and type 5 the most hypoechoic plaque were recorded. A medical history was taken with emphasis on risk factors present and a fasting lipid profile including ApoB and ApoA1 was determined. RESULTS: In the total population (N.=767) the mean (+/-SD) ApoB/ApoA1 ratio was 0.85 (+/-0.22). In linear regression analysis, the Apob/ApoA1 ratio was significantly associated with all the ultrasonic measurements of early atherosclerosis (intima media thickness, IMTcc, IMTmax, TPT and BPB). These findings remained significant after correcting for age, gender, smoking, hypertension and diabetes (P<0.001 for all). CONCLUSION: The results indicate that a high ApoB/ApoA1 ratio is associated not only with early atherosclerosis but also with hypoechoic (BPB) and by inference unstable plaques.
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Authors | A Panayiotou, M Griffin, N Georgiou, D Bond, T Tyllis, C Tziakouri-Shiakalli, C Fessas, A Nicolaides |
Journal | International angiology : a journal of the International Union of Angiology
(Int Angiol)
Vol. 27
Issue 1
Pg. 74-80
(Feb 2008)
ISSN: 0392-9590 [Print] Italy |
PMID | 18277343
(Publication Type: Journal Article)
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Chemical References |
- Apolipoprotein A-I
- Apolipoproteins B
- Cholesterol
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Topics |
- Aged
- Apolipoprotein A-I
(blood)
- Apolipoproteins B
(blood)
- Atherosclerosis
(blood, diagnostic imaging)
- Cardiovascular Diseases
(epidemiology)
- Carotid Artery, Common
(diagnostic imaging)
- Cholesterol
(blood)
- Female
- Femoral Artery
(diagnostic imaging)
- Humans
- Linear Models
- Male
- Middle Aged
- Prospective Studies
- Tunica Intima
(diagnostic imaging)
- Tunica Media
(diagnostic imaging)
- Ultrasonography
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