Decreased matriptase/HAI-1 ratio in advanced colorectal adenocarcinoma of Chinese patients.

Abstract

Matriptase is a serine protease expressed by tumors of surface epithelial origin. We tested the expressions of matriptase and hepatocyte growth factor activator inhibitor-1 (HAI-1) maybe associated with the progression of colorectal adenocarcinoma. Immunohistochemical analysis of matriptase and HAI-1 was performed in tissue microarray slides of 91 colorectal adenocarcinomas with various degrees. The matriptase scores in moderately (346.7 +/- 10.6) and poorly differentiated (248.1 +/- 12.9) were significantly lower than those in well differentiated (368.4 +/- 9.6) colorectal adenocarcinomas. The matriptase/HAI-1 ratios in poorly (1.8 +/- 0.4) and moderately differentiated (1.8 +/- 0.3) were significantly lower than in well differentiated (2.2 +/- 0.2) colorectal adenocarcinomas. Otherwise, the matriptase scores and matriptase/HAI-1 ratio showed significant reverse correlation with more advanced TNM stages of colorectal adenocarcinomas in Chinese patients. In conclusion, pharmacological inhibitors of matriptase may not be effective treatment for advanced colorectal adenocarcinomas.

• Authors: Wen-Chiuan Tsai, Lai-Fa Sheu, You-Chen Chao, Ann Chen, Hung Chiang, Jong-Shiaw Jin
• Journal: The Chinese journal of physiology (Chin J Physiol) Vol. 50 Issue 5 Pg. 225-31 (Oct 31 2007) ISSN: 0304-4920 [Print] India
• PMID: 18274158 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Proteinase Inhibitory Proteins, Secretory
• SPINT1 protein, human
• Serine Endopeptidases
• matriptase

Topics

• Adenocarcinoma (enzymology, pathology)
• Aged
• Asian People
• China
• Colorectal Neoplasms (enzymology, pathology)
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Neoplasm Staging
• Proteinase Inhibitory Proteins, Secretory (metabolism)
• Serine Endopeptidases (metabolism)
• Survival Rate
• Time Factors