Abstract | BACKGROUND: METHODS AND RESULTS: Tc-99m-Sestamibi was injected in 14 patients who had chest pain without ST elevation, who subsequently developed enzymatic evidence of myocardial infarction within 24 hours. Tomographic imaging was performed 1-6 hours after injection. Thirteen of 14 patients showed significant perfusion defects indicative of acute myocardial infarction consistent with absent perfusion (20 +/- 15% of the left ventricle; range, 2-53%); one patient had normal images. Because of the absence of definitive electrocardiographic changes, only five patients received reperfusion therapy within 6 hours of the onset of chest pain. Regional wall motion abnormalities were present in nine of nine patients undergoing contrast ventriculography and correlated with the location of the Tc-99m-Sestamibi perfusion defect. At the time of subsequent coronary angiography, total arterial occlusion was present in 11 of the 14 patients. The infarct-related artery could be identified in 13 of the 14 patients. In six of these 13 patients, the left circumflex was the infarct-related artery. CONCLUSIONS: Patients who have chest pain without electrocardiographic ST elevation may have arterial occlusion and significant myocardium at risk. Tc-99m-Sestamibi imaging may be of benefit in identifying these patients early so that they can be considered for acute reperfusion therapy.
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Authors | T F Christian, I P Clements, R J Gibbons |
Journal | Circulation
(Circulation)
Vol. 83
Issue 5
Pg. 1615-20
(May 1991)
ISSN: 0009-7322 [Print] United States |
PMID | 1827054
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Organotechnetium Compounds
- Technetium Tc 99m Sestamibi
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Topics |
- Aged
- Aged, 80 and over
- Angiography
- Coronary Angiography
- Electrocardiography
- Female
- Heart
(physiopathology)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(physiopathology)
- Organotechnetium Compounds
- Risk Factors
- Technetium Tc 99m Sestamibi
- Tomography
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