Multicenter evaluation of efficacy, tolerability and safety of a new first-line antihypertensive drug, isradipine, in a Latin-American population.

Isradipine, a new antihypertensive dihydropyridine calcium antagonist, was evaluated for its efficacy, tolerability, and safety in 91 ambulatory patients who had mild-to-moderate hypertension. The design of the present study included a two-week wash-out period after confirmation of disease, followed by 12 weeks of active treatment with 2.5 mg isradipine twice daily. Patients were switched from other antihypertensive drugs, mainly diuretics and beta-blockers. The dose of isradipine remained virtually unchanged throughout the study and resulted in a mean decrease of 22 mm Hg in systolic blood pressure (SBP) (P less than .00001) and 19 mm Hg in diastolic blood pressure (DBP) (P less than .00001). Heart rate was unchanged (difference of -1 beats/min), as was the mean body weight of the study patients. Isradipine was generally well tolerated. Side effects were few and, when present, tended to diminish and eventually disappear during the treatment period. All of the clinical laboratory parameters tested and electrocardiograph intervals remained unchanged. In conclusion, these results indicate that isradipine is a novel drug which is highly effective and well tolerated in the treatment of mild to moderate hypertension in this group of patients.
AuthorsG Gómez, E Melgarejo, J Narváez, G Gamarra, G Restrepo, L Acevedo, A Izurieta
JournalAmerican journal of hypertension (Am J Hypertens) Vol. 4 Issue 2 Pt 2 Pg. 128S-130S (Feb 1991) ISSN: 0895-7061 [Print] UNITED STATES
PMID1827002 (Publication Type: Clinical Trial, Journal Article, Multicenter Study)
Chemical References
  • Antihypertensive Agents
  • Pyridines
  • Isradipine
  • Adult
  • Aged
  • Antihypertensive Agents (adverse effects, standards, therapeutic use)
  • Blood Pressure (drug effects)
  • Body Weight (drug effects)
  • Cohort Studies
  • Colombia (epidemiology)
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Hypertension (drug therapy, epidemiology, physiopathology)
  • Isradipine
  • Male
  • Middle Aged
  • Muscle, Smooth, Vascular (drug effects)
  • Pyridines (adverse effects, standards, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: