Abstract | PURPOSE: Bmi-1 is a Polycomb group member which participates in many physiological processes as well as in a wide spectrum of cancers. The aim of this study was to investigate Bmi-1 expression in non-small cell lung cancer (NSCLC) in respect to clinicopathological features and therapeutic outcomes. METHODS: Immunohistochemical staining for Bmi-1 was performed on tissue microarrays (TMAs) constructed from 179 formalin-fixed and paraffin-embedded NSCLC samples (106 squamous, 58 adeno-, and 15 large cell carcinomas). Data were subject to statistical analysis by SPSS. RESULTS: Overall evaluation of all tumor cases showed that 20 (11.43%) were negative, 37 (21.14%) showed weak, 65 (37.14%) moderate and 57 (32.57%) strong nuclear positivity for Bmi-1. Statistical analysis of our data revealed that the expression of Bmi-1 was significantly higher in stage III (P = 10(-6)) and stage IV (P = 10(-5)) tumors compared to stages I and II tumors. The administration of adjuvant chemotherapy significantly increased DFS at stage I and II patients who did not express Bmi-1 when compared to their Bmi-1 positive counterparts (P = 0.05). CONCLUSIONS: Our results suggest that Bmi-1 is significantly associated with progression of NSCLC and might serve as a prognostic marker of adverse disease outcome.
|
Authors | Katerina Vrzalikova, Joseph Skarda, Jiri Ehrmann, Paul G Murray, Eduard Fridman, Jury Kopolovic, Petra Knizetova, Marian Hajduch, Jiri Klein, Vitezslav Kolek, Lenka Radova, Zdenek Kolar |
Journal | Journal of cancer research and clinical oncology
(J Cancer Res Clin Oncol)
Vol. 134
Issue 9
Pg. 1037-42
(Sep 2008)
ISSN: 0171-5216 [Print] Germany |
PMID | 18264721
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- BMI1 protein, human
- Nuclear Proteins
- Proto-Oncogene Proteins
- Repressor Proteins
- Polycomb Repressive Complex 1
|
Topics |
- Carcinoma, Non-Small-Cell Lung
(metabolism, pathology)
- Female
- Gene Expression Profiling
- Humans
- Immunohistochemistry
- Lung Neoplasms
(metabolism, pathology)
- Male
- Neoplasm Staging
- Nuclear Proteins
(genetics, metabolism)
- Polycomb Repressive Complex 1
- Prognosis
- Protein Array Analysis
- Proto-Oncogene Proteins
(genetics, metabolism)
- Repressor Proteins
(genetics, metabolism)
- Tissue Array Analysis
|