[Induction of spermatogenesis in hypogonadotrophic hypogonadism].

Abstract

BACKGROUND:

Reduced or missing sperm production is the main reason for infertility in a third of the couples who seek treatment. An uncommon cause of testicular failure is hypogonadotrophic hypogonadism. This review article discusses causes of this condition in men, medical treatment and prognosis with regard to fertility.

MATERIAL AND METHODS:

The review is based on a recent literature survey and many years of clinical experience with infertile patients.

RESULTS AND INTERPRETATION:

Hormonal regulation of the spermatogenesis involves complex interaction between structural elements (paracrine and endocrine) in the testicle and the endocrine system. Hormonal treatment of men with hypogonadotrophic hypogonadism comprises injections of gonadotrophins, administered by the patient in close cooperation with a specialist. It may be necessary to maintain this treatment for up to two years, but it is usually effective in initiating or restoring of spermatogenesis.

• Authors: Nan B Oldereid, Tom Tanbo
• Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke (Tidsskr Nor Laegeforen) Vol. 128 Issue 3 Pg. 327-9 (Jan 31 2008) ISSN: 0807-7096 [Electronic] Norway
• Vernacular Title: Induksjon av spermatogenese ved hypogonadotrop hypogonadisme.
• PMID: 18264160 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Chorionic Gonadotropin
• Gonadotropins
• Follicle Stimulating Hormone

Topics

• Azoospermia (drug therapy)
• Chorionic Gonadotropin (administration & dosage)
• Female
• Follicle Stimulating Hormone (administration & dosage)
• Gonadotropins (administration & dosage)
• Humans
• Hypogonadism (complications, drug therapy)
• Infertility, Male (drug therapy, etiology, therapy)
• Injections, Subcutaneous
• Male
• Pregnancy
• Pregnancy Outcome
• Prognosis
• Sperm Injections, Intracytoplasmic
• Spermatogenesis (drug effects)