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[Treatment of legionellosis with ofloxacin in kidney transplanted patients. Lack of interaction with cyclosporin A].

Abstract
Seven cases of legionellosis were observed in a series of 81 renal transplant recipients. In the 6 patients with functional graft, pneumonia occurred 17 days on average after the beginning of transplant rejection treatment. The diagnosis was made by bronchoalveolar lavage: the direct immunofluorescence antigen technique was positive in 5 cases and culture in 6 cases. Legionella pneumophila sero-groups 5 and 1 were identified in one and 5 patients respectively. Six of the 7 patients were treated with ofloxacin. This fluoroquinolone was effective in all cases. It was administered as single therapy in 3 patients and did not interfere with ciclosporin A metabolism. Ofloxacin given in mean doses of 400 mg per day adjusted to renal function proved to be a simple, effective and well tolerated treatment of legionellosis in transplant recipients receiving ciclosporin A.
AuthorsA Wynckel, O Toupance, J P Melin, C David, S Lavaud, T Wong, D Lamiable, J Chanard
JournalPresse medicale (Paris, France : 1983) (Presse Med) Vol. 20 Issue 7 Pg. 291-3 (Feb 23 1991) ISSN: 0755-4982 [Print] France
Vernacular TitleTraitement des légionelloses par ofloxacine chez le transplanté rénal. Absence d'interférence avec la ciclosporine A.
PMID1826354 (Publication Type: Journal Article, Review)
Chemical References
  • Cyclosporins
  • Ofloxacin
Topics
  • Adult
  • Cyclosporins (adverse effects, blood, metabolism)
  • Drug Interactions
  • Female
  • Humans
  • Immunosuppression Therapy (adverse effects, methods)
  • Kidney (drug effects)
  • Kidney Diseases (chemically induced)
  • Kidney Transplantation
  • Legionellosis (drug therapy, etiology)
  • Male
  • Middle Aged
  • Ofloxacin (pharmacology, therapeutic use)

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