Abstract |
Seven cases of legionellosis were observed in a series of 81 renal transplant recipients. In the 6 patients with functional graft, pneumonia occurred 17 days on average after the beginning of transplant rejection treatment. The diagnosis was made by bronchoalveolar lavage: the direct immunofluorescence antigen technique was positive in 5 cases and culture in 6 cases. Legionella pneumophila sero-groups 5 and 1 were identified in one and 5 patients respectively. Six of the 7 patients were treated with ofloxacin. This fluoroquinolone was effective in all cases. It was administered as single therapy in 3 patients and did not interfere with ciclosporin A metabolism. Ofloxacin given in mean doses of 400 mg per day adjusted to renal function proved to be a simple, effective and well tolerated treatment of legionellosis in transplant recipients receiving ciclosporin A.
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Authors | A Wynckel, O Toupance, J P Melin, C David, S Lavaud, T Wong, D Lamiable, J Chanard |
Journal | Presse medicale (Paris, France : 1983)
(Presse Med)
Vol. 20
Issue 7
Pg. 291-3
(Feb 23 1991)
ISSN: 0755-4982 [Print] France |
Vernacular Title | Traitement des légionelloses par ofloxacine chez le transplanté rénal. Absence d'interférence avec la ciclosporine A. |
PMID | 1826354
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Adult
- Cyclosporins
(adverse effects, blood, metabolism)
- Drug Interactions
- Female
- Humans
- Immunosuppression Therapy
(adverse effects, methods)
- Kidney
(drug effects)
- Kidney Diseases
(chemically induced)
- Kidney Transplantation
- Legionellosis
(drug therapy, etiology)
- Male
- Middle Aged
- Ofloxacin
(pharmacology, therapeutic use)
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