Effect of polylactic acid film barrier on intra-abdominal adhesion formation.
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| Abstract | PURPOSE: The aim of the present study was to evaluate the efficacy of an absorbable polylactic acid film barrier in preventing postoperative intra-abdominal adhesions, inflammation, and fibrosis in an animal model. METHODS: Thirty Wistar albino rats were divided into treatment and control groups. All rats underwent laparotomy with subsequent cecal wall abrasion and abdominal wall injury. The treatment group had a polylactic acid film barrier placed between the cecal and abdominal injured surfaces while control group received nothing. The animals were sacrificed on postoperative day 21. Three observers graded the intra-abdominal adhesions and resected specimens for histological examination of fibrosis and inflammation. Fibrosis, inflammation, and adhesions were graded using a quantitative scoring system. RESULTS: The treatment group showed significantly less adhesions and inflammation (P < 0.05), while there was no significant difference in the amount of fibrosis. Statistical correlations between adhesion-inflammation, adhesion-fibrosis, and inflammation-fibrosis were also significant (P < 0.05). CONCLUSIONS: Placement of polylactic acid film barriers between injured surfaces is associated with a significantly reduced rate of postoperative adhesions and inflammation. This may be a promising result for reducing the morbidity and costs related to postoperative adhesions.
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| Authors | Eren Ersoy, Vedat Ozturk, Aylin Yazgan, Mehmet Ozdogan, Haldun Gundogdu |
| Journal | The Journal of surgical research (J Surg Res) Vol. 147 Issue 1 Pg. 148-52 (Jun 01 2008) ISSN: 0022-4804 [Print] United States |
| PMID | 18262551 (Publication Type: Journal Article) |
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