Anti-inflammatory effects of combined treatment with acetyl salicylic acid and atorvastatin in haemodialysis patients affected by Normal Weight Obese syndrome.

Abstract

Low-grade inflammation is a common feature of chronic kidney disease (CKD) and persistent systemic inflammation is thought to be a strong predictor of cardiovascular events. Inflammation plays a role in determining the serum albumin levels in haemodialysis patients (HD) independently of the nutritional status. Increased cardiovascular mortality in CKD has been associated with the increased incidence of obesity in uremic patients. Ingenbleek suggested a prognostic inflammation and nutritional index (PINI), based on serum albumin, pre-albumin, C-reactive protein, and alpha1 acid glycoprotein, to identify and to follow up acutely ill patients at risk of major complications. The aims of the present study were: to verify the incidence of Normal Weight Obese (NWO) syndrome; to evaluate by PINI the effect of 8 weeks acetyl salicylic (100 mg/die) and atorvastatin (10 mg/die) combined treatment on chronic inflammation in 52 selected HD patients. Laboratory evaluation, anthropometric and body composition measurements were detected. At baseline the 56.25% of non-obese, the 84.21% of pre-obese-obese, and the 41.17% of NWO women showed PINI values >1 (normal status PINI<1). After the pharmacological treatment, high significant (P<0.001) reduction in lipid profile, an elevated increase of HDL levels, and a significant reduction of inflammatory markers were obtained. Firstly, our results showed that ASA and atorvastatin combined treatment was effective in reducing inflammatory status in HD patients independently of body composition: at the end of the study only 7.49% of the patients exhibited PINI>1. Further studies will be necessary to understand the causes of inflammation in non-responder patients.

• Authors: Laura Di Renzo, Annalisa Noce, Sandro De Angelis, Natascia Miani, Nicola Di Daniele, Carmela Tozzo, Antonino De Lorenzo
• Journal: Pharmacological research (Pharmacol Res) Vol. 57 Issue 2 Pg. 93-9 (Feb 2008) ISSN: 1043-6618 [Print] Netherlands
• PMID: 18262432 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Anticholesteremic Agents
• Cholesterol, HDL
• Heptanoic Acids
• Prealbumin
• Pyrroles
• Serum Albumin
• C-Reactive Protein
• Atorvastatin
• Aspirin

Topics

• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology, therapeutic use)
• Anticholesteremic Agents (pharmacology, therapeutic use)
• Aspirin (pharmacology, therapeutic use)
• Atorvastatin
• Body Fat Distribution
• Body Mass Index
• Body Weight
• C-Reactive Protein (metabolism)
• Cardiovascular Diseases (complications, prevention & control)
• Cholesterol, HDL (blood, metabolism)
• Drug Therapy, Combination
• Female
• Heptanoic Acids (pharmacology, therapeutic use)
• Humans
• Inflammation (diagnosis, drug therapy, metabolism)
• Kidney Failure, Chronic (complications, metabolism, therapy)
• Lipid Metabolism
• Male
• Middle Aged
• Nutrition Assessment
• Obesity (complications, metabolism)
• Prealbumin (metabolism)
• Pyrroles (pharmacology, therapeutic use)
• Renal Dialysis
• Serum Albumin (metabolism)
• Syndrome