Abstract | BACKGROUND & AIMS: METHODS: RESULTS: One hundred sixteen patients underwent 160 courses of PDT. The incidence of stricture formation after index PDT was 16% (19/116). For all PDT courses, the overall incidence of stricture was 23% (37/160). Stricture rate was significantly higher after a second PDT course compared with index PDT (43% vs 16%, P = .0007). There was no association between post- PDT stricture development and age, gender, body mass index, or prior endoscopic mucosal resection. Patients who developed a stricture had a longer length of Barrett's esophagus before treatment than those who did not develop a stricture (7.7 vs 5.7 cm for index PDT only, P = .025; 7.4 vs 5.7 cm for all PDT courses, P = .007). Length of Barrett's esophagus, multiple PDT courses, and presence of intramucosal carcinoma on pretreatment pathology were independent predictors of post- PDT stricture in a stepwise logistic regression analysis controlling for treatment variables, including treatment length. CONCLUSIONS:
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Authors | Patrick Yachimski, William P Puricelli, Norman S Nishioka |
Journal | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
(Clin Gastroenterol Hepatol)
Vol. 6
Issue 3
Pg. 302-8
(Mar 2008)
ISSN: 1542-7714 [Electronic] United States |
PMID | 18255349
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Photosensitizing Agents
- Dihematoporphyrin Ether
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Topics |
- Aged
- Barrett Esophagus
(pathology, therapy)
- Dihematoporphyrin Ether
(adverse effects, therapeutic use)
- Esophageal Neoplasms
(pathology, therapy)
- Esophageal Stenosis
(diagnosis, epidemiology, etiology)
- Female
- Follow-Up Studies
- Humans
- Incidence
- Male
- Neoplasm Staging
- Odds Ratio
- Photosensitizing Agents
(adverse effects, therapeutic use)
- Phototherapy
(adverse effects)
- Prognosis
- Retrospective Studies
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