HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Transitory or long-lasting immunity to Leishmania major infection: the result of immunogenicity and multicomponent properties of histone DNA vaccines.

Abstract
The present studies were designed to analyze the immunization against cutaneous leishmaniosis with plasmids encoding Leishmania histones either individually or genetically linked in tandem, or with cocktails encoding the four nucleosomal histones (H2A, H2B, H3 and H4). Genetic immunization of BALB/c mice with the individual histones only resulted in a delay in lesion development, whereas the immunization with any one of the plasmids encoding a pair of histones provided stronger, though still partial protection against Leishmania major infection compared to the combination of the four histones. These results provide direct evidence that all four nucleosomal histones of Leishmania are necessary to maintain complete protection against L. major reinfection.
AuthorsJavier Carrión, Cristina Folgueira, Carlos Alonso
JournalVaccine (Vaccine) Vol. 26 Issue 9 Pg. 1155-65 (Feb 26 2008) ISSN: 0264-410X [Print] Netherlands
PMID18255202 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Protozoan
  • Histones
  • Nucleosomes
  • Protozoan Proteins
  • Protozoan Vaccines
  • Vaccines, DNA
Topics
  • Amino Acid Sequence
  • Animals
  • Antibodies, Protozoan (blood)
  • COS Cells
  • Chlorocebus aethiops
  • Female
  • Histones (chemistry, genetics, immunology)
  • Immunization
  • Leishmania major (genetics, immunology, pathogenicity)
  • Leishmaniasis, Cutaneous (immunology, parasitology, prevention & control)
  • Mice
  • Mice, Inbred BALB C
  • Molecular Sequence Data
  • Nucleosomes
  • Plasmids
  • Protozoan Proteins (administration & dosage, genetics, immunology)
  • Protozoan Vaccines (administration & dosage, genetics, immunology)
  • Th1 Cells (immunology)
  • Th2 Cells (immunology)
  • Vaccines, DNA (administration & dosage, genetics, immunology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: