Abstract | BACKGROUND: METHODS: This study included 50 patients with keloids and hypertrophic scars. Bleomycin was administered through multiple superficial puncture technique. Three applications were given at intervals of 15 days each, followed by a fourth and final application 2 months after the last application. Final results were read 2 months after the last application. Results were evaluated according to change in size as follows: Group Response. a. Complete flattening (100% regression). b. Significant flattening (75-99% regression). c. Adequate flattening (50-74% regression). d. Inadequate flattening (less than 50%). Patients were assessed for any complication of bleomycin (systemic as well as local) and recurrence of keloids and hypertrophic scars. Regular follow-up for side-effects was done for 18 months. RESULTS: Out of 50 patients, complete flattening was observed in 22 cases (44%); significant flattening in 11 cases (22%); and adequate flattening was observed in 7 cases (14%). Only 10 cases (20%) did not show any satisfactory flattening. Pruritus was relieved completely in 40 patients (88.88%). Recurrence was seen in seven patients. CONCLUSION:
Bleomycin is easy to administer, is cheap, shows high regression rate, and has minimum complication and recurrence. Thus, it can be used as the first-line treatment modality for management of keloids and hypertrophic scars.
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Authors | Himanshu Aggarwal, Anurag Saxena, Parvinder S Lubana, R K Mathur, D K Jain |
Journal | Journal of cosmetic dermatology
(J Cosmet Dermatol)
Vol. 7
Issue 1
Pg. 43-9
(Mar 2008)
ISSN: 1473-2165 [Electronic] England |
PMID | 18254811
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Bleomycin
(administration & dosage, adverse effects)
- Child
- Cicatrix, Hypertrophic
(drug therapy, etiology, pathology)
- Cytotoxins
(administration & dosage, adverse effects)
- Drug Administration Schedule
- Female
- Follow-Up Studies
- Humans
- Injections, Intralesional
- Keloid
(drug therapy, etiology, pathology)
- Male
- Middle Aged
- Pruritus
(drug therapy, etiology)
- Recurrence
- Skin
(injuries, pathology)
- Treatment Outcome
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