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Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression.

AbstractBACKGROUND:
Odontogenic neoplasms have some morphologic overlap with salivary gland neoplasms, many of which show myoepithelial differentiation. In the 1980s, an ultrastructural study identified a population of myoepithelial-like cells in calcifying epithelial odontogenic tumor. Myoepithelial derived tumors have since been shown to have distinct immunohistochemical profiles.
METHODS:
We examined a series of odontogenic neoplasms, including 11 ameloblastomas, four calcifying epithelial odontogenic tumors, five glandular odontogenic cysts (GOCs), and five keratocystic odontogenic tumors with a panel of myoepithelial-associated immunohistochemical stains. We also assessed representative control examples of oral mucosa, odontogenic rests, and dentigerous cysts.
RESULTS:
All of the neoplastic and non-neoplastic oral epithelium-derived entities share a p63-positive, high molecular weight cytokeratin (CK5/6)-positive immunophenotype. Calponin reactivity was at least focally present in two of four calcifying epithelial odontogenic tumors, three of five GOCs, and 10 of 11 ameloblastomas; the sole completely non-reactive ameloblastoma represents a lung metastasis. One case of calcifying epithelial odontogenic tumor was focally positive for glial fibrillary acidic protein. However, other more definitive markers of myoepithelial differentiation, including S-100 and smooth muscle actin, were negative. Two of three calcifying epithelial odontogenic tumors and five of five GOCs were also positive for a low molecular weight cytokeratin (CK7).
CONCLUSIONS:
Ameloblastomas, GOCs, and calcifying epithelial odontogenic tumors show a distinctive immunophenotype which overlaps with that of myoepithelial-derived salivary gland neoplasms but does not provide definitive support for myoepithelial differentiation.
AuthorsDita Gratzinger, Mohamed E Salama, Catherine F Poh, Robert V Rouse
JournalJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (J Oral Pathol Med) Vol. 37 Issue 3 Pg. 177-84 (Mar 2008) ISSN: 1600-0714 [Electronic] Denmark
PMID18251942 (Publication Type: Journal Article)
Chemical References
  • Antigens, Neoplasm
  • CKAP4 protein, human
  • Calcium-Binding Proteins
  • Keratins, Type II
  • Membrane Proteins
  • Microfilament Proteins
  • Muscle Proteins
  • calponin
Topics
  • Ameloblastoma (pathology)
  • Antigens, Neoplasm (biosynthesis)
  • Calcium-Binding Proteins (biosynthesis)
  • Cell Differentiation
  • Epithelial Cells (pathology)
  • Gene Expression
  • Humans
  • Immunophenotyping
  • Keratins, Type II (biosynthesis, immunology)
  • Membrane Proteins (biosynthesis)
  • Microfilament Proteins (biosynthesis)
  • Muscle Cells (pathology)
  • Muscle Proteins (biosynthesis)
  • Odontogenic Cysts (pathology)
  • Odontogenic Tumors (pathology)
  • Retrospective Studies
  • Salivary Gland Neoplasms (pathology)

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