Evaluation of a new premedication protocol for administration of equine rabies immunoglobulin in patients with hypersensitivity.

Abstract

OBJECTIVES:

The present study was undertaken to standardize skin testing and to develop a safe and effective premedication protocol for administration of ERIG in those with skin test positivity/hypersensitivity.

METHODS:

A method of grading of skin testing was developed using injection histamine as a positive control. This was evaluated by using it on 517 subjects who had severe (WHO category III) exposure to rabies. A premedication protocol consisting of injections pheniramine, ranitidine, hydrocortisone and adrenaline was evaluated by using it on fifty one subjects who were skin test positive/hypersensitive to ERIG.

RESULTS:

The premedication protocol was safe and effective as all the S1 subjects could be administered the full dose of ERIG despite being skin test positive/hypersensitive to ERIG. Besides the premedication drugs/protocol did not affect the immune response to vaccine and ERIG therapy.

• Authors: M K Sudarshan, N S Kodandaram, G M Venkatesh, B J Mahendra, D H Ashwath Narayana, B G Parasuramalu
• Journal: Indian journal of public health (Indian J Public Health) 2007 Apr-Jun Vol. 51 Issue 2 Pg. 91-6 ISSN: 0019-557X [Print] India
• PMID: 18240468 (Publication Type: Journal Article)

Chemical References

• Glucocorticoids
• Histamine H1 Antagonists
• Immunoglobulins
• Rabies Vaccines
• Ranitidine

Topics

• Adolescent
• Adult
• Aged
• Animals
• Child
• Child, Preschool
• Clinical Protocols
• Drug Hypersensitivity (complications, prevention & control)
• Female
• Glucocorticoids (therapeutic use)
• Histamine H1 Antagonists (therapeutic use)
• Horses
• Humans
• Immunoglobulins (administration & dosage)
• Infant
• Infant, Newborn
• Intradermal Tests
• Male
• Middle Aged
• Premedication
• Rabies (complications, prevention & control)
• Rabies Vaccines (administration & dosage)
• Ranitidine (therapeutic use)