Moxifloxacin versus ampicillin + gentamicin in the therapy of experimental Listeria monocytogenes meningitis.

Abstract

OBJECTIVES:

This study aimed to compare the antibacterial activity of moxifloxacin and ampicillin + gentamicin in the treatment of Listeria monocytogenes meningitis in a rabbit meningitis model.

METHODS:

Meningitis was induced by direct inoculation of a clinical strain isolated from an immunocompromised patient (10(7) cfu/mL) into the cisterna magna of New Zealand rabbits. After 16 h of incubation, rabbits were separated into four groups: moxifloxacin (M), ampicillin + gentamicin (A), ampicillin + gentamicin 2 (A2) and control (C). Group M received 20 mg/kg moxifloxacin at the end of the incubation time and 5 h later by intravenous (i.v.) route. Group A received ampicillin (30 mg/kg/h) and gentamicin (2.5 mg/kg/h) by i.v. route with continuous infusion for 8 h in 36 mL of 0.9% NaCl, group A2 received the same dosage of gentamicin and ampicillin in two different 36 mL 0.9% NaCl solutions and group C did not receive any treatment. Cerebrospinal fluid (CSF) samples (0.1-0.25 mL) were obtained 16 and 24 h after induction of meningitis.

RESULTS:

At the end of the 16 h of incubation, CSF bacterial counts were similar in all groups (P > 0.05). At the final stage of the study (24 h after induction of meningitis), bacterial counts in all treatment groups were significantly lower than the control group (P < 0.05). When the three treatment groups were compared, bacterial counts were found to be similar (P > 0.05).

CONCLUSIONS:

These data suggest that antibacterial activity of moxifloxacin is similar to ampicillin + gentamicin in the treatment of experimental L. monocytogenes meningitis of rabbits.

• Authors: Oguz Resat Sipahi, Tuncer Turhan, Husnu Pullukcu, Sebnem Calik, Meltem Tasbakan, Hilal Sipahi, Bilgin Arda, Tansu Yamazhan, Sercan Ulusoy
• Journal: The Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 61 Issue 3 Pg. 670-3 (Mar 2008) ISSN: 1460-2091 [Electronic] England
• PMID: 18230687 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aza Compounds
• Fluoroquinolones
• Gentamicins
• Quinolines
• Ampicillin
• Moxifloxacin

Topics

• Ampicillin (administration & dosage)
• Animals
• Aza Compounds (administration & dosage)
• Disease Models, Animal
• Drug Therapy, Combination
• Fluoroquinolones
• Gentamicins (administration & dosage)
• Humans
• Male
• Meningitis, Listeria (drug therapy, microbiology, physiopathology)
• Moxifloxacin
• Quinolines (administration & dosage)
• Rabbits