Abstract |
Immunohistochemical study revealed overexpression of prolactin receptors in central and peripheral cells of intrahepatic grafts from H27 rat hepatoma without changes in compartmentalization compared to hepatocytes of intact animals. Experiments with gonadectomized animals showed that the hormonal regulation of prolactin receptors in both types of tumor cells does not differ from that in normal liver cells (positive estrogen-dependent regulation and negative androgen-dependent regulation).
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Authors | T Yu Ostroukhova, O A Kurasheva, A A Rozenkrants, O V Smirnova |
Journal | Bulletin of experimental biology and medicine
(Bull Exp Biol Med)
Vol. 143
Issue 3
Pg. 308-11
(Mar 2007)
ISSN: 0007-4888 [Print] United States |
PMID | 18225749
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Female
- Immunohistochemistry
- Liver Neoplasms, Experimental
(metabolism)
- Male
- Neoplasm Transplantation
- Orchiectomy
- Ovariectomy
- Rats
- Receptors, Prolactin
(metabolism)
- Sex Characteristics
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