Abstract | OBJECTIVES: DESIGN AND METHODS: We analyzed serum concentrations of the calcification inhibitor matrix Gla protein (MGP) in a large cohort of patients suffering from PXE (n=101), 34 first-degree relatives and 67 healthy controls. Moreover, we determined the distribution of the two MGP promoter polymorphisms c.-7G>A and c.-138T>C in the three cohorts. RESULTS: We found significantly lower total MGP concentrations in the sera of PXE patients compared to healthy controls (p=0.0002). Furthermore, higher serum MGP concentrations could be correlated with a later PXE onset. Analysis of MGP promoter polymorphism frequencies revealed one MGP haplotype to be a potential protective co-factor in PXE. CONCLUSIONS: Our findings point to a role of the local calcification inhibitor MGP in PXE manifestation.
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Authors | Doris Hendig, Ralf Zarbock, Christiane Szliska, Knut Kleesiek, Christian Götting |
Journal | Clinical biochemistry
(Clin Biochem)
Vol. 41
Issue 6
Pg. 407-12
(Apr 2008)
ISSN: 0009-9120 [Print] United States |
PMID | 18222176
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ABCC6 protein, human
- AHSG protein, human
- Blood Proteins
- Calcium-Binding Proteins
- Extracellular Matrix Proteins
- Multidrug Resistance-Associated Proteins
- alpha-2-HS-Glycoprotein
- matrix Gla protein
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Topics |
- Adult
- Aged
- Blood Proteins
(metabolism)
- Calcinosis
(metabolism, pathology)
- Calcium-Binding Proteins
(genetics, metabolism)
- Extracellular Matrix Proteins
(genetics, metabolism)
- Female
- Genotype
- Haplotypes
- Humans
- Male
- Middle Aged
- Multidrug Resistance-Associated Proteins
(genetics, metabolism)
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Pseudoxanthoma Elasticum
(metabolism, pathology)
- alpha-2-HS-Glycoprotein
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