Piper cubeba demonstrates anti-estrogenic and anti-inflammatory properties.

Abstract

This present study aims to investigate if P9605, an ethanolic extract of PIPER CUBEBA L, exhibits anti-estrogenic and anti-inflammatory properties. We found that P9605 significantly inhibited growth induced by beta-estradiol in MCF-7, a human breast cancer cell line. It inhibited aromatase activity, which is responsible for transforming androgens into estrogens. Competitive binding assays also indicated P9605 binding to both human recombinant estrogen a and beta receptors. Furthermore, this extract inhibited the activities of cyclo-oxygenases (COX-1 and COX-2) and 5-lipo-oxygenase (5-LOX), also it attenuated the induction of interleukin 6 (IL-6) in differentiated THP-1 cells stimulated by lipopolysaccharide (LPS). Taken together with our previous results, P9605 possesses anti-androgenic, anti-estrogenic and anti-inflammatory properties. These results support the potential use of P9605 in phytotherapy against benign prostatic hyperplasia (BPH).

• Authors: Jianying Yam, Alexei Schaab, Matthias Kreuter, Juergen Drewe
• Journal: Planta medica (Planta Med) Vol. 74 Issue 2 Pg. 142-6 (Feb 2008) ISSN: 0032-0943 [Print] Germany
• PMID: 18219597 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Estrogen Receptor Modulators
• Lignans
• Piper cubeba extract
• Plant Extracts
• Arachidonate 5-Lipoxygenase
• Cyclooxygenase 1
• Cyclooxygenase 2
• Thymidine

Topics

• Anti-Inflammatory Agents (pharmacology)
• Arachidonate 5-Lipoxygenase (drug effects, metabolism)
• Breast Neoplasms
• Cell Line, Tumor
• Cyclooxygenase 1 (drug effects, metabolism)
• Cyclooxygenase 2 (drug effects, metabolism)
• Estrogen Receptor Modulators (pharmacology)
• Female
• Humans
• Kinetics
• Lignans (pharmacology)
• Piper
• Plant Extracts (pharmacology)
• Thymidine (metabolism)