Two cases of Zoon's balanitis treated with pimecrolimus 1% cream.

Abstract

BACKGROUND:

Plasma cell balanitis is a disorder of the middle-aged and older uncircumcised male. Several treatments have been proposed to treat this disease, but plasma cell balanitis is often resistant to conventional therapy.

METHODS:

We decided to evaluate the efficacy and tolerability of pimecrolimus 1% cream in resistant Zoon's balanitis. We report two cases of resistant Zoon's balanitis treated with topical pimecrolimus 1% cream.

RESULTS:

One of the two patients had a complete regression of the lesion after 2 months of therapy. The other one had a great improvement of the lesion, but a hyperpigmented patch persisted on the glans.

CONCLUSION:

Pimecrolimus 1% cream may be a valuable second-line treatment for patients with steroid related side effects or with steroid and other conventional therapy resistant Zoon's balanitis, as well as for those rejecting circumcision.

• Authors: F Bardazzi, Angela Antonucci, F Savoia, R Balestri
• Journal: International journal of dermatology (Int J Dermatol) Vol. 47 Issue 2 Pg. 198-201 (Feb 2008) ISSN: 1365-4632 [Electronic] England
• PMID: 18211499 (Publication Type: Case Reports, Journal Article)

Chemical References

• Dermatologic Agents
• pimecrolimus
• Tacrolimus

Topics

• Administration, Topical
• Aged
• Balanitis (drug therapy)
• Dermatologic Agents (therapeutic use)
• Humans
• Male
• Tacrolimus (analogs & derivatives, therapeutic use)